2010 Fiscal Year Final Research Report
The role of SOG1, a novel transcription factor, in the DNA damage checkpoint
| Project/Area Number |
21770047
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Plant molecular biology/Plant physiology
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
YOSHIYAMA Kaoru Nara Institute of Science and Technology, バイオサイエンス研究科, 研究員 (10346322)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 植物分子機能 / DNAチェックポイント / DNAダメージ / 細胞周期 |
|---|
| Research Abstract |
DNA can be damaged by extracellular and intercellular insults such as ionizing radiation, some chemical agents and reactive oxygen species. The damaged DNA must be repaired to prevent loss or incorrect transmission of genetic information. Therefore, eukaryotic cells have DNA checkpoint system, which arrests the cell cycle in response to damaged or incompletely replicated DNA to provide time for the cell for repair damaged chromosome before entering mitosis. The purpose of this project is to make clear the mechanism of plant specific DNA checkpoint system. As a result, we showed that SOG1 plays an important role in DNA checkpoint, SOG1 functions at the root apical meristems and the shoot apical meristems, and SOG1 protein is modified in response to DNA damage.
|
