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2011 Fiscal Year Final Research Report

Identification and functional analysis of novel hypothalamic neuropeptides involved in energy homeostasis.

Research Project

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Project/Area Number 21770079
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionHiroshima University

Principal Investigator

IWAKOSHI Eiko  広島大学, 大学院・総合科学研究科, 研究員 (50311296)

Project Period (FY) 2009 – 2011
Keywords神経ペプチド / 鳥類 / 視床下部 / 摂食行動
Research Abstract

Recently, many neuropeptides involved in food intake have been identified in mammals and extensive studies have been performed to reveal their physiological functions. However, there are little studies on these neuropeptides in non-mammals. In this study, firstly we sought the novel RFamide peptide, 26RFa, in the avian species, as the aspect of energy homeostasis. In addition, we further investigated a novel precursor gene encoding neuropeptide which we have originally identified in the avian brain.

  • Research Products

    (9 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Identificationand structure-activity relationship of anantimicrobial peptide of the palustrin-2family isolated from the skin of theendangered frog Odorrana ishikawae2011

    • Author(s)
      Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K.
    • Journal Title

      Peptides

      Volume: 32 Pages: 2052-2057

    • Peer Reviewed
  • [Journal Article] Characterization ofnovel antimicrobial peptides from the skin ofthe endangered frog Odorrana ishikawae byshotgun cDNA cloning. Biochem. Biophys2011

    • Author(s)
      Iwakoshi-Ukena E, Soga M, Okada G, FujiiT, Sumida M, Ukena K.
    • Journal Title

      Res. Commun.

      Volume: 412 Pages: 673-677

    • Peer Reviewed
  • [Journal Article] Identification andcharacterization of antimicrobial peptidesfrom the skin of the endangered frogOdorrana ishikawae2011

    • Author(s)
      Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M.
    • Journal Title

      Peptides

      Volume: 32 Pages: 670-676

    • Peer Reviewed
  • [Journal Article] Identification, localization, and function of anovel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, Gprotein-coupled receptor-1032010

    • Author(s)
      Ukena K, Tachibana T, Iwakoshi-Ukena E, Saito Y, Minakata H, Kawaguchi R, Osugi T, Tobari Y, Leprince J, Vaudry H, Tsutsui K.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 2255-2264

    • Peer Reviewed
  • [Presentation] 視床下部における新規摂食調節関連遺伝子の発見2010

    • Author(s)
      岩越栄子、田中幸恵、橘哲也、浮穴和義
    • Organizer
      第35回日本比較内分泌学会大会静岡
    • Place of Presentation
      静岡
    • Year and Date
      2010-11-20
  • [Presentation] ニワトリの新規摂食調節関連遺伝子がコードしている神経ペプチドの摂食行動に及ぼす影響2010

    • Author(s)
      岩越栄子、橘哲也、古満芽久美、浮穴和義
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-20
  • [Remarks] 2010年の第35回日本比較内分泌学会大会において口頭発表した内容に対し、若手研究者最優秀発表賞を受賞した。

  • [Patent(Industrial Property Rights)] ポリペプチド、ポリペプチドの製造方法、摂食調節組成物および摂食量の調節方法2011

    • Inventor(s)
      浮穴和義、岩越栄子、益田恵子、古満芽久美
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      特許、特願2011-248006
    • Filing Date
      2011-11-11
  • [Patent(Industrial Property Rights)] ポリペプチド、摂食促進組成物および摂食量の促進方法2011

    • Inventor(s)
      浮穴和義、岩越栄子
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      特許、特願2011-065216
    • Filing Date
      2011-03-24

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Published: 2013-07-31  

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