2011 Fiscal Year Final Research Report
Function of lysophosphatidylserine in immune response
| Project/Area Number |
21770102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MAKIDE Kumiko 東北大学, 大学院・薬学研究科, 助教 (30519773)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リゾリン脂質 / 炎症 / GPCR / 産生酵素 |
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| Research Abstract |
Although it is reported that lysophosphatidylserine(LysoPS)has various cellular activities in vitro, very little is known about its presence, synthetic enzyme, receptor and patho-physiological roles. In this study, we showed that LysoPS is produced at inflamed sites in mice and PS-PLA1 is involved in its production. LysoPS was also found to suppress concanavalin A-induced hepatic injury in mice.
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[Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position2012
Author(s)
Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y, Nakamura S, Otani Y, Ohwada T, Aoki J.
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Journal Title
J Biochem
Volume: 151(5)
Pages: 511-8
Peer Reviewed
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[Journal Article] Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative2009
Author(s)
Iwashita M, Makide K, Nonomura T, Misumi Y, Otani Y, Ishida M, Taguchi R, Tsujimoto M, Aoki J, Arai H, Ohwada T.
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Journal Title
J Med Chem
Volume: 52(19)
Pages: 5837-63
Peer Reviewed
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