2010 Fiscal Year Final Research Report
Regulation of peroxisome matrix protein import by ubiquitin modification
| Project/Area Number |
21770117
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
OKUMOTO Kanji Kyushu University, 大学院・理学研究院, 助教 (20363319)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 細胞内小器官 / ユビキチン化 / タンパク質輸送 |
|---|
| Research Abstract |
Peroxisome, one of the intracellular organelle, includes various physiological functions and the deficiency causes fetal genetic diseases in human. This study clarified that import of peroxisomal matrix proteins into peroxisomes, the most important process in peroxisome biogenesis, is elaborately regulated by unique ubiquitin modification of Pex5p, a cytosolic receptor of peroxisome targeting signal type-1.
|
