2010 Fiscal Year Final Research Report
Effect of exosome-associated gangliosides on the assembly of amyloid-β protein
| Project/Area Number |
21770128
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Hokkaido University (2010)
National Institute for Longevity Sciences,NCGG (2009) |
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Principal Investigator |
YUYAMA Kohei Hokkaido University, 大学院・先端生命科学研究院, 特任助教 (80415546)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 糖質 / ガングリオシド / アルツハイマー病 |
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| Research Abstract |
Alzheimer's disease is pathologically featured by extraneuronal deposition of amyloid fibrils, which are composed of amyloid-β protein (Aβ). However, it still remains to be clarified how soluble monomeric Aβ assemble into fibrils. In the present study, we found that ganglioside GM1 is release from mouse primary cortical neurons, in the association with exosome. Furthermore, the exosome-associated GM1 accelerated the assembly of synthetic Aβ in vitro.
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