2010 Fiscal Year Final Research Report
analysis of lysophospholipid signaling in zebrafish
| Project/Area Number |
21770131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
HAMA Kotaro 東北大学, 大学院・薬学研究科, 助教 (20534481)
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| Project Period (FY) |
2009 – 2010
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| Keywords | リゾホスファチジン酸 / 受容体 / 産生酵素 / ゼブラフィッシュ |
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| Research Abstract |
The aim of this study is clarifying the molecular machinery of lysophospholipid signaling using zebrafish. We first modified several vectors using gal4-UAS system and transposon (tol2) to facilitate making transgenic lines. Using this vectors, we succeeded in establishing several transgenic lines. These are useful tools to elucidate the timing and the place in which lysophospholipid signaling functions. We succeeded in discovering several genes involved in some organogenesis. Zebrafish is considered as the lowest model organisms which possesses lysophospholipid signaling related genes. Our study shows that zebafish as a useful model organisms to elucidate the lysophospholipid signaling in vivo.
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