2012 Fiscal Year Final Research Report
Mechanisms involved in ghrelin degradation in circulation and identification of its processing enzymes.
| Project/Area Number |
21770149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Research Collaborator |
NISHI Yoshihiro 久留米大学, 医学部, 講師 (20352122)
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| Project Period (FY) |
2009 – 2012
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| Keywords | グレリン / 酵素 / ペプチドホルモン / 酵素 / 脂質修飾 / タンパク質精製 |
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| Research Abstract |
A peptide hormone ghrein has divers physiological actions including growth hormone release, appetite control and immunomodulation. In this study, the ghrelin deacylation enzyme (APT1) and two ghrelin peptidases (APC and TAFI) were purified from animal blood, and their cDNAs were isolated. The enzymatic processed formsshowed synergistic or distinctive roles in ghrelin actions such as cell differentiation.
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