2011 Fiscal Year Final Research Report
Cancer cell recognition by an activating-type Siglec
| Project/Area Number |
21770155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The Institute of Physical and Chemical Research (2011)
Osaka University (2009-2010) |
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Principal Investigator |
ANGATA Takashi 独立行政法人理化学研究所, 糖鎖認識研究チーム, チームリーダー (40371017)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 免疫 / シアル酸 / シアリルTn / レクチン / シグレック / 上皮間葉転換 / TGF-β |
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| Research Abstract |
Siglec-15 is one of the receptors that recognize glycans containing sialic acids, and is involved in the immune cell activation. In this study, we identified a soluble factor that induces expression of Siglec-15 on myeloid cells. We also found that the interaction between glycan ligand on tumor cells and Siglec-15 on myeloid cells induces enhanced myeloid expression of TGF-β, which is involved in epithelial-mesenchymal transition of cancer cells.
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