2010 Fiscal Year Final Research Report
Peptidomics-based mining of novel antimicrobial peptides
| Project/Area Number |
21770156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
OSAKI Tsukasa 独立行政法人国立循環器病研究センター, 分子薬理部, 特任研究員 (60380565)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ホルモンと生理活性物質 / 抗菌ペプチド / ペプチドーム |
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| Research Abstract |
Recently, it has been an increasing problem of drug-resistant bacteria in a hospital. One of candidates effective against these bacteria is an antimicrobial peptide. This study was aimed at discovery of novel antimicrobial peptides from identified peptides using peptidomic analysis. We screened them based on antimicrobial activity and found two novel antimicrobial peptides including AMP-IBP5. AMP-IBP5 is an intramolecular disulfide-linked 22-residue amidated peptide. This peptide showed antimicrobial activity stronger than β-defensin-2 and could become candidates for new drugs.
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