2010 Fiscal Year Final Research Report
Is there common mechanism in the divergent PAS domain signal transduction?
| Project/Area Number |
21770175
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
YAMAZAKI Yoichi Nara Institute of Science and Technology, 物質創成科学研究科, 助教 (40332770)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 光生物学 / シグナル伝達 / タンパク質間相互作用 / PASドメイン |
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| Research Abstract |
To elucidate activation mechanism retained in PAS domain family protein, two different Photoactive Yellow Protein (PYP) were investigated as model proteins. In the results, 1) N-terminal regions in both PYPs owned functionally important part in each PYP, 2) co-factor binding region was almost same each other but small differences affects the co-factors features, 3) C-terminal structural scaffold mainly decided each PYP propensities ,the other part in each sequence affected by coupling with the C-terminal region.
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