2010 Fiscal Year Final Research Report
Ascertaining the indispensable rotor region for the rotation of F1-ATPase
| Project/Area Number |
21770176
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
FURUIKE Shou Osaka Medical College, 医学部, 助教 (60392875)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 1分子観察 / ATP合成酵素 / 回転トルク / 光学顕微鏡 / 回転分子モーター |
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| Research Abstract |
F1-ATPase(F_1) is an ATP-driven molecular rotary motor. The "axle-less F_1" that the rotor portion in the stator cylinder is truncated, can rotate in the correct direction. Motivated by this finding, we tried to determine the indispensable rotor region(s) for the F_1 rotation. The contrast mutant with the axle-less F_1, that has only the rotor portion in the stator cylinder, unexpectedly, rotated at>100 rotations/s. The rotor of F_1 may have no essential region (amino-acid sequence) to rotate itself.
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[Journal Article] Chemo-mechanical coupling in the rotary molecular motor F1-ATPase2010
Author(s)
K.Adachi, S.Furuike, M.D.Hossain, H.Itoh, K.Kinosita, Jr., Y.Onoue, R.Shimo-Kon
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Journal Title
in Springer Series in Chemical Physics(Single Molecule Spectroscopy in Chemistry, Physics and Biology. Nobel Symposium" Astrid Graslund, Rudolf Rigler, and Jerker Widengren, Eds, Springer, Heidelberg) Vol.96
Pages: 271-285
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