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2010 Fiscal Year Final Research Report

Role of RNA-binding proteins in mitochondrial function

Research Project

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Project/Area Number 21770180
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Molecular biology
Research InstitutionUniversity of Tsukuba

Principal Investigator

NAIKI Takahiro  University of Tsukuba, 大学院・人間総合科学研究科, 助教 (70420081)

Project Period (FY) 2009 – 2010
KeywordsRNA結合タンパク質
Research Abstract

RNA-binding proteins coordinate protein expression through post-transcriptional regulations. We demonstrated that hnRNPK localizes in Stress Granules and has a role for the regulation of ATP level during stress condition through RNA regulation. Furthermore, we revealed that RBM42, an hnRNPK binding protein, functions in the regulation of ATP synthesis. We also obtained evidences that hnRNPK and RBM42 coordinate cell proliferation by regulating novel target mRNAs.

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Published: 2012-02-13   Modified: 2016-04-21  

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