2010 Fiscal Year Final Research Report
Relationship between mediator recruitment and transcriptional activity in the yeast heat shock protein.
| Project/Area Number |
21770192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Okayama University of Science |
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Principal Investigator |
HASHIKAWA Naoya Okayama University of Science, 理学部, 講師 (60434982)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 転写 / HSP / HSE |
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| Research Abstract |
HSP play a center role in the stress response. The promoter of HSP gene exist HSE sequence, HSF protein binds to HSE and regulates transcription of HSP.
Mediator is a multiprotein complex that functions as a transcriptional coactivator. Mediator complex is required for the successful transcription of nearly all gene regulated RNA polymerase II in yeast.
In this study, we revealed that the necessity of mediator changed by the difference of HSE sequence.
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