2010 Fiscal Year Final Research Report
Study of the molecular mechanism of oxidative stress response induced by mitochondrial ROS
| Project/Area Number |
21770208
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SHIBUYA Toshiharu Osaka University, 医学系研究科, 助教 (70448033)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 酸化ストレス / ミトコンドリア / 細胞内情報伝達 |
|---|
| Research Abstract |
An experimental assay system was employed to generate excessive ROS in the mitochondria in a precisely controlled spatio-temporal manner. Using mammalian cells and worm C. elegans generating mitochondrial ROS, I analyzed the stress response and the molecular mechanism induced by mitochondrial ROS in vitro and in vivo. I revealed that factors involved in the mitochondrial permeability transition (Cyclophilin D and Ca++) were contributed to the mitochondrial oxidative stress response.
|
