2010 Fiscal Year Final Research Report
Live imaging of protein transport through the Golgi apparatus
| Project/Area Number |
21770215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
TOKITA Kumi (松浦 公美) Kyushu University, 大学院・医学研究院, 学術研究員 (50415296)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞構造・機能 / ゴルジ体 |
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| Research Abstract |
The ER and Golgi are dynamic organelles that assemble and disassemble during the cell cycle. To elucidate the molecular mechanisms underlying these changes in organelle organization, I searched for novel factors that play a fundamental role in biogenesis and maintenance of the ER and Golgi, using live-imaging technique as a powerful tool. Using modified in vitro ER reformation assay technique and by biochemical approach, I identified a soluble factor sufficient for building and maintaining tubular ER lattice by itself.
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