2011 Fiscal Year Final Research Report
Metabolicmachineryandbiologicalfunctionofmembransphingolipids
| Project/Area Number |
21770217
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
MOTOHIRO Tani 九州大学, 理学研究院, 准教授 (20452740)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生体膜 / スフィンゴ脂質 / リン脂質 / 脂質代謝酵素 |
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| Research Abstract |
Sphingolipids, the major lipid components of the eukaryotic plasma membrane, playcritical roles in many physiologically important events. In this study, we fbcused onsphingolipid-metabolizing enzymes and investigated physiological function of membrane complex sphingolipids and ceramides by using the yeast Saochazomyces cerevisiae as a model organism. The results were summarized below :[ 1] impairment of metabolism of aspecific subtype of complex sphingolipid, phosphoinositides, and phosphatidylserine causessynthetic lethal phenotype,[ 2] specific complex sphingolipid and phosphatidylserine arecoordinately involved in vesicular trafficking between early endosomes and the Golgi compartments,[ 3] hydroxylation states and chain lengths of fatty acids in ceramide arecritical structural factors fbr toxicity of ceramide.
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