2010 Fiscal Year Final Research Report
Regulation of the onset of neuronal migration in the developing mouse neocortex
| Project/Area Number |
21770230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITOH Yasuhiro The University of Tokyo, 分子細胞生物学研究所, 助教 (50508108)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞分化 |
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| Research Abstract |
During the neocortical development, neural precursor cells are located in the ventricular zone by attaching their apical process to the ventricular surface through cadherin-based adherens junctions and form a pseudostratified epithelial structure. Once these cells commit to become neurons or intermediate neuronal progenitors, they delaminate and start migration toward the pial surface. However, it has remained unclear how the detachment from the neuroepithelium, the first step of radial migration, is coordinated with neuronal fate commitment. This study revealed a mechanism that links these two processes.
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