2010 Fiscal Year Final Research Report
Functional analysis of Kinesin superfamily protein in kidney development
| Project/Area Number |
21770232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
TERABAYASHI Takeshi Kumamoto University, 発生医学研究所・COEリサーチ・アソシエイト (40452429)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 腎臓発生 / キネシンスーパーファミリー蛋白質 / 細胞骨格 / 微小管 / 細胞接着 |
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| Research Abstract |
In this study, we performed the functional analysis of Kif26b, a member of kinesin super family proteins. Kif26b is expressed in the metanephric mesenchymes, a population of multipotent kidney progenitors. Disruption of Kif26b causes kidney agenesis because of impaired ureteric bud attraction. In the Kif26b-null metanephros, compact adhesion between mesenchymal cells adjacent to the ureteric buds and the polarized distribution of integrin alpha 8 were impaired, resulting in failed maintenance of Gdnf, a critical ureteric bud attractant. Overexpression of Kif26b in vitro caused increased cell adhesion through interactions with nonmuscle myosin. Thus, Kif26b is essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds.
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[Journal Article] Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.2010
Author(s)
Uchiyama Y., Sakaguchi Y., Terabayashi T., Inenaga T., Inoue S., Kobayashi C., Oshima N., Kiyonari H., Nakagata N.,Sato Y., Sekiguchi K., Miki H., Fujimura S.Tanaka S.S., Nishinakamura R.
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Journal Title
Proc.Natl.Acad.Sci.USA 107
Pages: 9240-9245
Peer Reviewed
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