• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Analysis for developmental mechanisms of protrusion and outgrowth

Research Project

  • PDF
Project/Area Number 21770239
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research Institution大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2010)
National Institutes of Natural Sciences Okazaki Research Facilities (2009)

Principal Investigator

MIYAGAWA Shinichi  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 (30404354)

Project Period (FY) 2009 – 2010
Keywords器官形成 / 外生殖器 / シグナリングセンター / 成長因子
Research Abstract

Embryonic appendicular structures, including the developing external genitalia, are suitable models to analyze the developmental mechanisms of organ protrusion and outgrowth. Although several studies have evaluated individual functions of different growth factors on appendicular growth, the coordinated function of signaling cascades is poorly understood. Our results provide new insights into the integration of growth factor signaling (i.e. hedgehog, Wnt and Fgfs) in the appendicular developmental programs regulating external genitalia development. We also demonstrated the interaction of such growth factors and sex steroid hormones (androgens) during later stage of external genital development.

  • Research Products

    (9 results)

All 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Molecular mechanisms of induction of persistent changes by estrogenic chemicals on female reproductive tracts and external genitalia.2011

    • Author(s)
      Miyagawa S, Sato M, Iguchi T.
    • Journal Title

      J Steroid Biochem Mol Biol in press

    • Peer Reviewed
  • [Journal Article] Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation.2011

    • Author(s)
      Murashima A, Miyagawa S, Ogino Y, Nishida-Fukuda H, Araki K, Matsumoto T, Kaneko T, Yoshinaga K, Yamamura KI, Kurita T, Kato S, Moon AM, Yamada G.
    • Journal Title

      Endocrinology in press

    • Peer Reviewed
  • [Journal Article] Genetic analysis of hedgehog signaling in ventral body wall development and the onset of omphalocele formation.2011

    • Author(s)
      Matsumaru D, Haraguchi R, Miyagawa S, Motoyama J, Nakagata N, Meijlink F, Yamada G.
    • Journal Title

      PLoS One 20

      Pages: e16260

    • Peer Reviewed
  • [Journal Article] Estrogen receptor ESR1 is indispensable for the induction of persistent vaginal change by neonatal 5alpha-dihydrotestosterone exposure in mice.2010

    • Author(s)
      Miyagawa S, Katsu Y, Ohta Y, Sudo T, Lubahn DB, Iguchi T.
    • Journal Title

      Biol Reprod 82

      Pages: 497-503

    • Peer Reviewed
  • [Journal Article] Dosage dependent hedgehog signals integrated with Wnt/b-catenin regulate embryonic external genitalia formation as an appendicular program.2009

    • Author(s)
      Miyagawa S, Moon A, Haraguchi R, Inoue C, Harada M, Nakahara C, Suzuki K, Matsumaru D, Kaneko T, Matsuo, I, Yang L, Taketo MM, Iguchi T, Evans SM, Yamada G.
    • Journal Title

      Development 136

      Pages: 3969-3978

    • Peer Reviewed
  • [Journal Article] Genetic integrations of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.2009

    • Author(s)
      Miyagawa S, Satoh Y, Haraguchi R, Suzuki K, Iguchi T, Taketo MM, Nakagata N, Matsumoto T, Takeyama K, Kato S, Yamada G.
    • Journal Title

      Mol Endcrinol. 23

      Pages: 871-880

    • Peer Reviewed
  • [Presentation] 外生殖器雄性化過程におけるヘッジホッグシグナルの解析2010

    • Author(s)
      宮川信一、原口竜摩、井口泰泉、山田源
    • Organizer
      第29回日本アンドロロジー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-30
  • [Presentation] Estrogen receptor a is indispensable for the induction of persistent vaginal change by neonatal 5a-dihydrotestosterone exposure.2009

    • Author(s)
      Miyagawa S., Katsu Y., Iguchi T.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
  • [Remarks] ホームページ

    • URL

      http://www.nibb.ac.jp/%7Ebioenv1/index-j.html

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi