2010 Fiscal Year Final Research Report
MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors
Project/Area Number |
21770248
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Developmental biology
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
SHIBATA Mikihito The Institute of Physical and Chemical Research, ボディプラン研究グループ, 研究員 (50391975)
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Project Period (FY) |
2009 – 2010
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Keywords | マウス / 発生 / 端脳 / 大脳新皮質 / microRNA-9 |
Research Abstract |
microRNA-9-2 and microRNA-9-3 double-mutant mice demonstrate that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the developing telencephalon by regulating the expression of multiple transcription factors. Also we found that the activity of miR-9 is finely modulated by AU-rich RNA-binding proteins and Msi1 during development.
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Research Products
(5 results)