2012 Fiscal Year Final Research Report
Mechanisms of the PCP signal transduction to bend neuroepithelial layer
| Project/Area Number |
21770250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kobe University (2011-2012)
The Institute of Physical and Chemical Research (2009-2010) |
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Principal Investigator |
NISHIMURA Tamako 神戸大学, 自然科学系先端融合研究環・重点研究部 (40415261)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 神経管 / 平面内極性 / F-アクチン / ミオシン |
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| Research Abstract |
Neural tube is the precursor of the central nervous system, andformed by the bending of the neural plate along the body axis, although underlying mechanisms were not completely understood. We found that at the apical cell-cell contact sites of the neuroepithelial cells, which constitute neural plate, actomyosin cytoskeleton is activated and contracted in the direction perpendicular to the body axis, leading to a tube formation. Furthermore, we uncovered a novel signaling pathway in which the planar cell polarity signaling regulates the polarized activation of actomyosin in the bending neural plate.
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Research Products
(4 results)
