2011 Fiscal Year Final Research Report
The association among folate intakes, homocysteine and atherosclerosis.
| Project/Area Number |
21770267
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied anthropology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAZATO Mio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (00380973)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 葉酸 / 動脈硬化 / 頸動脈内中膜複合体厚 / 心臓足首血管指数 / ホモシステイン / 離島 / へき地 |
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| Research Abstract |
This study was investigated the association among homocysteine, folate, methylene-tetrahydrofolate reductase gene C677Tpolymorphism, and clinical evaluations of atherosclerosis on three remote islands with different populations. Although homocysteine reversely correlated to folate, homocysteine or folate were not correlate to clinical evaluations of atherosclerosis. The homocysteine has lower values in island with less population, and it has divergence among homocysteine, serum folate and erythrocyte folate values. They are suggested that homocysteine were affected by environmental factors excluding MTHFR gene polymorphism or folate intake, and erythrocyte folate was better than serum folate as indicator of folate status.
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[Journal Article] Lack of an association between E-selectin gene polymorphisms and the risk of Kawasaki disease2012
Author(s)
Shirakawa T, Ikeda K, Nishimura S, Kuniba H, Nakashima K, Motomura H, Mizuno Y, Zaitsu M, Nakazato M, Maeda T, Hamasaki Y, Hara T, Moriuchi H
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Journal Title
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[Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan2011
Author(s)
Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
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Journal Title
ACTA MEDICA NAGASAKIENSIA
Volume: (55)
Pages: 47-54
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[Journal Article] Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women2010
Author(s)
Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, Maeda T
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Journal Title
Biomarkers
Volume: 15(4)
Pages: 340-4
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[Journal Article] A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma2009
Author(s)
Ichinose S, Nakamura M, Maeda M, Ikeda R, Wada M, Nakazato M, Ohba Y, Takamura N, Maeda T, Aoyagi K, Nakashima K
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Journal Title
Biomed Chromatogr
Volume: 23(9)
Pages: 935-9
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