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2011 Fiscal Year Final Research Report

Cell morphogenesis network regulates coordination between cell morphogenesis and cell growth

Research Project

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Project/Area Number 21780097
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied biochemistry
Research InstitutionHiroshima University

Principal Investigator

KUME Kazunori  広島大学, 大学院・先端物質科学研究科, 助教 (80452613)

Project Period (FY) 2009 – 2011
Keywords細胞形態形成 / 細胞増殖
Research Abstract

The aim of this study is to understand coordinated regulation between cell morphogenesis and cell growth in fission yeast. Although cell morphogenesis that has an essential role in expression of cellular function is properly regulated by cell cycle, the precise mechanism remains elusive. In fission yeast, the MOR pathway promotes actin polarization to cell tips in interphase, whereas the SIN pathway pathway drives actomyosin ring assembly and cytokinesis. In this study, We show that the SIN pathway inhibits MOR pathway in mitosis and this regulation is important for completion of cytokinesis and coordination of cytoskeletal remodeling at the mitosis-to-interphase transition.

  • Research Products

    (11 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] 分裂酵母の2つのHippo関連経路のクロストーク2011

    • Author(s)
      久米一規, 五島徹也, 平田大
    • Journal Title

      実験医学

      Volume: 29 Pages: 445-448

  • [Journal Article] Kume, Takayuki Koyano, Yoshikazu Ohya, Takashi Toda, Dai Hirata, Fission yeastgerminal center(GC) kinase Ppk11interacts with Pmo25 and plays an auxiliaryrole in concert with the morphogenesis Orb6network(MOR) in cell morphogenesis2010

    • Author(s)
      Tetsuya Goshima, KazunoriKume
    • Journal Title

      Journal Biological Chemistry

      Volume: 28545 Pages: 35196-35025

    • Peer Reviewed
  • [Journal Article] Themitosis-to-interphase transition iscoordinated by cross talk between the SINand MOR pathways Schizosaccharomycespombe2010

    • Author(s)
      Samriddha Ray, Kazunori Kume, SnehaGupta, Mohan Balasubramanian, DaiHirata, Dannel McCollum
    • Journal Title

      Journal Cell Biology

      Volume: 1905 Pages: 793-805

    • Peer Reviewed
  • [Journal Article] Search for kinases related to transition ofgrowth polarity in fission yeast2010

    • Author(s)
      Takayuki Koyano, Kazunori Kume, ManabuKonishi, Takashi Toda, Dai Hirata
    • Journal Title

      BioscienceBiotechnology Biochemistry

      Volume: 74 Pages: 1129-1133

    • Peer Reviewed
  • [Presentation] The signaling pathwaylinking DNA replication to cellpolarization2011

    • Author(s)
      Kazunori Kume
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-16
  • [Presentation] The signaling pathwaylinking DNA replication to cellpolarization2011

    • Author(s)
      Kazunori Kume
    • Organizer
      The 6th InternationalFission Yeast Meeting
    • Place of Presentation
      Martin Conference Center U. S. A
    • Year and Date
      2011-06-26
  • [Presentation] Cross talk between SIN and MOR pathways in fission yeast2011

    • Author(s)
      Kazunori Kume
    • Organizer
      6th UK-Japan Cell Cycle Workshop
    • Place of Presentation
      Low Wood Hotel U. K.
    • Year and Date
      2011-04-12
  • [Presentation] The mitosis to interphase transition is coordinated bycrosstalk between the SIN and MOR pathways in S. pombe2010

    • Author(s)
      Kazunori Kume
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-08
  • [Presentation] Regulation of morphogenesis Orb6 network(MOR) by SIN2009

    • Author(s)
      Kazunori Kume
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-09
  • [Presentation] Regulation of morphogenesis Orb6 network by SIN2009

    • Author(s)
      Kazunori Kume
    • Organizer
      The 5th International Fission Yeast Meeting
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都)
    • Year and Date
      2009-10-27
  • [Remarks]

    • URL

      http://www.hiroshima-u.ac.jp/adsm/bio/saibou/

URL: 

Published: 2013-07-31  

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