2010 Fiscal Year Final Research Report
Studies of cGMP signaling in neurons.
| Project/Area Number |
21780098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YUASA Keizo The University of Tokushima, 大学院・ソシオテクノサイエンス研究部, 助教 (70363132)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 情報伝達 |
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| Research Abstract |
1. Rho effector, rhotekin, was phosphorylated by cGK I. Phosphorylated rhotekin was disassociated from cGK I, and significantly suppressed lysophosphatidic acid- and rho- induced neurite retraction in Neuro2A cells.
2. cGK I interacted with and phosphorylated transient receptor potential channel subfamily C member 7 (TRPC7), contributing to the quick and accurate regulation of calcium influx and CREB phosphorylation.
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Research Products
(8 results)
