2010 Fiscal Year Final Research Report
Search for inhibitors of NADH-fumarate reductase from second metabolites of bacteria, actinomycetes and fungi
| Project/Area Number |
21780115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
MORI Mihoko Kitasato University, 大学院・感染制御科学府, 助教 (20425648)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生物活性物質 / 寄生虫 / 感染症 / 機器分析 / 精製 / ミトコンドリア電子伝達系 |
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| Research Abstract |
Screening for inhibitors of NADH-fumarate reductase was conducted using about 8,200 samples of cultured broths of fungi, actinomycetes and bacteria. About 2% of the broths inhibited the enzyme. Active components containing in most of the hit samples were hydrophillic. Fumaric acid or small organic compounds or inorganic salts showed the inhibitory activity was suggested. On the other hand, two hydrophobic active compounds were found in the hit samples. One was (4E)-5-(2-methylphenyl)-4-pentenoic acid from a broth of Streptomyces sp. This was the first NADH-fumarate reductase inhibitor produced by actinomycetes. Anothers were pentaene compounds, prugosene A1 and two new analogs isolated from cultured broth of Penicillium sp FKI-5329. They showed strong inhibitory activity against NADH-fumarate reductase.
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[Journal Article] Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp.
Author(s)
Mori M., Morimoto, H., Kim, Y-P., Ui, H., Nonaka, K., Masuma, R., Sakamoto, K., Kita, K., Tomoda, H., Shiomi, K., Omura, S.
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Journal Title
FKI-3389. Tetrahedron in press.
Peer Reviewed
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[Remarks] ホームページ等
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