2010 Fiscal Year Final Research Report
Metabolomics-based evaluation of aryl-hydrocarbon receptor-dependent variation of metabolites
| Project/Area Number |
21780125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Kobe University |
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Principal Investigator |
NISHIUMI Shin Kobe University, 医学研究科, 特命助教 (20514706)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アリール炭化水素受容体 / メタボローム解析 / 代謝物 |
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| Research Abstract |
The aryl hydrocarbon receptor (AhR) is known to be activated by its ligands, resulting in regulation of various genes. However, the biological functions of AhR have been not elucidated yet. Therefore, the influence of AhR on the biological functions was investigated by the metabolome analysis, which is the comprehensive analysis of metabolites. As a result, it was demonstrated that the activation of AhR leads to alteration of various metabolites. In addition, it was found that the metabolite profile is different between the presence and absence of AhR expression.
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[Journal Article] Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport.2010
Author(s)
Kawano Y., Nishiumi S., Tanaka S., Nobutani K., Miki A., Yano Y., Seo Y., Kutsumi H., Ashida H., Azuma T., Yoshida M.
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Journal Title
Archives of Biochemistry and Biophysics 504
Pages: 221-227
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[Journal Article] A role of the aryl hydrocarbon receptor in attenuation of colitis.
Author(s)
Furumatsu K., Nishiumi S., Kawano Y., Ooi M., Yoshie T., Shiomi Y., Kutsumi H., Ashida H., Fujii-Kuriyama Y., Azuma T., Yoshida M.
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Journal Title
Digestive Diseases and Sciences in press
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