2010 Fiscal Year Final Research Report
Control of expression of genes related to metabolic syndrome by food components
| Project/Area Number |
21780130
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Saga University |
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Principal Investigator |
NAGAO Koji Saga University, 農学部, 准教授 (10336109)
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| Project Period (FY) |
2009 – 2010
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| Keywords | メタボリックシンドローム / 脂肪組織 / 疾患遺伝子 / 食環境 |
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| Research Abstract |
Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in metabolic syndrome. We found that the dietary intake of powdered whole Panellus serotinus (Mukitake) and its extracts alleviate NAFLD in obese, diabetic db/db mice. Our study demonstrated that Mukitake displays at least two different physiological actions that alleviate NAFLD : one through the reduction of inflammatory damage by its suppression in MCP-1 production and the other through an increase of the serum adiponectin level and the prevention of visceral fat accumulation.
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[Journal Article] Dietary soy protein isolate, and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats.2009
Author(s)
I.Ikeda, M.Kudo, T.Hamada, K.Nagao, Y.Oshiro, M.Kato, T.Sugawara, T.Yamahira, H.Ito, S.Tamaru, M.Sato, K.Imaizumi, S.Nagaoka, T.Yanagita
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Journal Title
J.Nutr.Sci.Vitaminol 55巻
Pages: 252-256
Peer Reviewed
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