2010 Fiscal Year Final Research Report
Inhibitory mechanisms of food factors on the progression of prostate cancer
| Project/Area Number |
21780132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
HARADA Naoki Osaka Prefecture University, 生命環境科学研究科, 助教 (00529141)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 機能性食品 / レスベラトロール / アンドロゲン受容体 / アセチル化 / 転写 / ホルモン療法 / 前立腺がん |
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| Research Abstract |
We studied on the molecular mechanisms underlying the development of hormone therapy-resistant prostate cancer. The C-teminal truncated form of androgen receptor (AR) was produced when prostate cancer cells were incubated in the absence of ligand or in the presence of androgen antagonist. It was expected that the short form of AR acts as transcription factor in a ligand-independent manner. Resveratol inhibited DNA binding of AR, presumably by decreasing its level of acetylation. In addition, it was speculated that resveratrol inhibits the transcriptional activity of the short form of AR.
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