2011 Fiscal Year Final Research Report
Mechanism of the enhancement of hepatic insulin action induced by protein malnutrition
| Project/Area Number |
21780134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SUZUKI Yuka (SUZUKI TOYOSHIMA Yuka) 日本医科大学, 老人病研究所, 助教 (70516070)
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| Project Period (FY) |
2009 – 2011
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| Keywords | インスリン / 肝臓 / タンパク質栄養 |
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| Research Abstract |
Protein malnutrition induces lipid accumulation in the liver, which was liked with the enhancement of insulin signaling in the liver. Furthermore, in contrast to the liver, in white adipose tissue(WAT), protein malnutrition suppresses insulin action. Taken together with our results, when energy utilization is reduced under protein malnutrition, energy that is not utilized is preferentially incorporated into the liver and synthesized to lipids. The enhancement of insulin signaling in the liver and the suppression of insulin signaling in WAT may play important roles in the preferential distribution of lipids in the liver during protein malnutrition.
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