2010 Fiscal Year Final Research Report
Regulation of intestinal immune balance by intake of vitamin A
| Project/Area Number |
21780137
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
YOKOTA Aya Tokushima Bunri University, 薬学部, 助教 (30446075)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 腸管免疫 / ビタミンA / レチノイン酸 / 経口免疫寛容 / 制御性T細胞 / サイトカイン / 細胞接着分子 / ケモカイン |
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| Research Abstract |
The vitamin A metabolite, retinoic acid, plays an essential role in the homing of lymphocytes to the small intestinal tissues. Retinoic acid also affects differentiation of naive CD4^+ T cells to Foxp3^+ inducible regulatory T cells and proinflammatory Th17 cells. It has been suggested thus that vitamin A might be involved in the regulation of intestinal immune balance. In the present study, we found that oral administration of antigen strongly induced T cell responses and antibody responses in vitamin A-deficient mice but not vitamin A-sufficient control mice. These results suggest that vitamin A deficiency may cause food allergy.
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