2010 Fiscal Year Final Research Report
The origin and purpose of fast skeletal muscle myosin heavy chain gene cluster of vertebrates
| Project/Area Number |
21780198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fisheries chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
IKEDA Daisuke Kitasato University, 海洋生命科学部, 講師 (00466806)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ミオシン重鎖 / クラスター / ゲノム / 筋発生 / ヤツメウナギ |
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| Research Abstract |
Myosin heavh chain (MYH) is essential protein for a wide range of motile processes in eukaryotic cells and fast skeletal MYH genes (MYHs) formed clusters in mammals and teleosts. In the present study, we found that the fast skeletal MYHs formed a cluster also in the lamprey, agnathan vertebrate. Moreover, in vivo promoter assay demonstrated that lamprey fast skeletal MYH promoters could drive reporter gene to express in the fast skeletal muscle in zebrafish embryo. These results suggest that in the early vertebrates, fast skeletal MYHs had already formed clusters and the basic mechanism for transcriptional control of skeletal muscle development had been determined.
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