2010 Fiscal Year Final Research Report
Characterization of abortion related factor of intracellular protozoan parasite Neospora caninum and its application for vaccine development
| Project/Area Number |
21780262
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
NISHIKAWA Yoshifumi Obihiro University of Agriculture and Veterinary Medicine, 原虫病研究センター, 准教授 (90431395)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 寄生虫 / 原虫 / ワクチン / 流産 / 垂直感染 |
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| Research Abstract |
The aim of this study is to characterize an abortion related factor of Neospora caninum, NcGRA7, for development of vaccine against neosporosis. This study showed that NcGRA7 could stimulate immune cells. Moreover, we developed vaccine based on NcGRA7 and could control the parasite infection in mouse model. The present study indicates the positive results for the vaccine development against neosporosis.
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[Journal Article] Construction of Neospora caninum stably expressing TgSAG1 and evaluation of its protective effects against Toxoplasma gondii infection in mice.2010
Author(s)
Zhang G, Huang X, Boldbaatar D, Battur B, Battsetseg B, Zhang H, Yu L, Li Y, Luo Y, Cao S, Goo YK, Yamagishi J, Zhou J, Zhang S, Suzuki H, Igarashi I, Nishikawa Y, Xuan X.
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Journal Title
Vaccine. 28(45)
Pages: 7243-7247
Peer Reviewed
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