2011 Fiscal Year Final Research Report
Investigation of the role of giantin in the rat development
| Project/Area Number |
21780266
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
KATAYAMA Kentaro 日本獣医生命科学大学, 獣医学部・獣医学科, 講師 (50508869)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨軟骨形成不全症 / 軟骨形成 / Giantin / ゴルジ体 / ラット |
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| Research Abstract |
Insertional mutation in giantin(Golgb1) gene is responsible for the developmental abnormalities including osteochondrodysplasia and systemic edema in ocd/ocd rat. ocd/ocd rats exhibited the delayed mesenchymal condensation in chondrogenesis, abnormalities of lyphatic vessels and enhanced vascular permeability. The present findings indicate that the important role of giantin in normal embryonic development, especially chondrogenesis, and formation of lymphatic and blood vessels.
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