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2010 Fiscal Year Final Research Report

Discover of novel bioactive peptide and application to mammmal

Research Project

  • PDF
Project/Area Number 21780268
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionUniversity of Miyazaki

Principal Investigator

IDA Takanori  University of Miyazaki, IR推進機構, 助教 (00381088)

Research Collaborator MURAKAMI NOBORU  宮崎大学, 農学部・獣医学科, 教授
KUME Kazuhiko  熊本大学, 発生医学研究所, 准教授
SANO Hiroko  お茶の水女子大学, お茶大アカデミックプロダクション, 特任助教
TOMINAGA Hatsumi  宮崎大学, 技術職員
Project Period (FY) 2009 – 2010
Keywords新規生理活性ペプチド / オーファンGPCR / ショウジョウバエ
Research Abstract

It is very important to discover a novel bioactive peptide to the orphan receptor. However, the number of novel bioactive peptides in mammals that have been discovered has recently been tapering off. To change through this situation, I have selected drosophila, a useful model organism, as a subject to search for and hopefully discover novel bioactive peptides. As a result, a new bioactive peptide was discovered, and analyzed in the drosophila.

  • Research Products

    (14 results)

All 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Continuous Antagonism of the Ghrelin Receptor Results in Early Induction of Salt-Sensitive Hypertension2011

    • Author(s)
      Sato T, Nakashima Y, Nakamura Y, Ida T, Kojima M
    • Journal Title

      J Mot Neuroscie 43(2)

      Pages: 193-9

    • Peer Reviewed
  • [Journal Article] Comparison of feeding suppression by the anorexigenic hormones neuromedin U and neuromedin S in rats2010

    • Author(s)
      Nakahara K, Katayama T, Ida T, Mori K, Miyazato M, Kangawa K, Murakami N
    • Journal Title

      J.Endocrinology 207(2)

      Pages: 185-193

    • Peer Reviewed
  • [Journal Article] Purification and characterization of caprine ghrelin and its effect on growth hormone release2010

    • Author(s)
      Ida T, Miyazato M, Lin XZ, Kaiya H, Sato T, Nakahara K, Murakami N, Kangawa K, Ko j ima M
    • Journal Title

      J Mol Neuroscie 42(1)

      Pages: 99-105

    • Peer Reviewed
  • [Journal Article] Neuromedin U is necessary for normal gastrointestinal motility and is regulated by serotonin2010

    • Author(s)
      Nakashima Y, Ida T, SatoT, Nakamura Y, Takahashi T, Mori K, Miyazato M, Kangawa K, Kusukawa J, Kojima M
    • Journal Title

      Ann N Y Acad Sci 1200

      Pages: 104-11

    • Peer Reviewed
  • [Journal Article] ニューロメジンU2010

    • Author(s)
      井田隆徳、児島将康
    • Journal Title

      ニューロメジンS日本臨床肥満症第2版 68

      Pages: 83-86

  • [Journal Article] Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin 0-acyltransferase as well as n-octanoic acid2009

    • Author(s)
      Takahashi T, Ida T, Sato T, Nakashima Y, Nakamura Y, Tsu j i A, Kojima M
    • Journal Title

      J Biochem 146(5)

      Pages: 675-82

    • Peer Reviewed
  • [Journal Article] Ghrelin 0-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor2009

    • Author(s)
      Ohgusu H, Shirouzu K, Nakamura Y, Nakashima Y, Ida T, Sato T, Ko j ima M
    • Journal Title

      Biochem Biophys Res Commun 386(1)

      Pages: 153-158

    • Peer Reviewed
  • [Presentation] モデル生物を利用した新規生理活性ペプチドの探索2010

    • Author(s)
      井田隆徳、粂和彦、佐藤貴弘、児島将康
    • Organizer
      第150回日本獣医学会学術集会
    • Place of Presentation
      帯広畜産大学
    • Year and Date
      2010-09-16
  • [Presentation] ショウジョウバエオーファン受容体に対する新規生理活性ペプチドの探索と解析2010

    • Author(s)
      井田隆徳、粂和彦、佐藤貴弘、児島将康
    • Organizer
      第7回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-07
  • [Presentation] Identification of novel peptides for orphan GPCRs in Drosophila2010

    • Author(s)
      Ida T, Sato T, Kojima M
    • Organizer
      14th International Congress of Enddocrinology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-29
  • [Presentation] ショウジョウバエオーファン受容体に対するリガンド探索2009

    • Author(s)
      井田隆徳、高橋知子、中島義基、中村祐輔、佐藤貴弘、児島将康
    • Organizer
      日本内分泌学会第27回内分泌代謝学サマーセミナー
    • Place of Presentation
      福井
    • Year and Date
      2009-07-16
  • [Presentation] Deorphanized drosophila GPCRs2009

    • Author(s)
      井田隆徳、高橋知子、佐藤貴弘、児島将康
    • Organizer
      第6回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-08
  • [Remarks] ホームページ等

    • URL

      http://www.cc.miyazaki-u.ac.jp/a0d203u/index.html

  • [Patent(Industrial Property Rights)] ショウジョウバエ由来生理活性ペプチド2010

    • Inventor(s)
      井田隆徳, 児島将康, 粂和彦
    • Industrial Property Rights Holder
      久留米大学 熊本大学
    • Industrial Property Number
      特願:2010-045816
    • Filing Date
      2010-03-02

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Published: 2012-02-13   Modified: 2016-04-21  

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