2010 Fiscal Year Final Research Report
Structural bioinformatics analysis of antigenic changes in influenza virus hemagglutinin
| Project/Area Number |
21780272
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IGARASHI Manabu Hokkaido University, 人獣共通感染症サーチセンター, 特任助教 (10374240)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 人畜共通感染症 |
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| Research Abstract |
The hemagglutinin (HA) of influenza A viruses undergoes antigenic changes to escape from antibody-mediated immune pressure. In order to control for influenza, it is important to understand the patterns of amino acid substitutions in the past and then to predict possible antigenic changes of the HA molecules in future. In this study, we analyzed the change of HA antigenic structures in the evolutionary process of influenza viruses in the human population, by using structural bioinformatics approach. Based on the results, we predicted possible amino acid substitutions that might be associated with future antigenic change of 2009 H1N1.
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Research Products
(24 results)
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[Journal Article] Characterization of influenza A viruses isolated from wild waterfowls in Zambia2011
Author(s)
Simulundu E, Ishii A, Igarashi M, Mweene A, Suzuki Y, Hang'ombe B, Namangala B, Moonga L, Manzoor R, Ito K, Nakamura I, Sawa H, Sugimoto C, Kida H, Simukonda C, Chansa W, Chulu J, Takada A
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Journal Title
Peer Reviewed
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[Journal Article] Genetic characterization and susceptibility on poultry and mammal of H7N6 subtype avian influenza virus isolated in Japan in 2009.2011
Author(s)
Uchida Y, Kanehira K, Mase M, Takemae N, Watanabe C, Ito T, Igarashi M, Ito K, Takada A, Sakoda Y, Okamatsu M, Yamamoto Y, Nakamura K, Kida H, Hiromoto Y, Tsuda T, Saito T
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Journal Title
Vet Microbiol. 147(1-2)
Pages: 1-10
Peer Reviewed
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[Journal Article] Enzyme-linked immunosorbent assay for the detection of filovirus species-specific antibodies.2010
Author(s)
Nakayama E, Yokoyama A, Miyamoto H, Igarashi M, Kishida N, Matsuno K, Marzi A, Feldmann H, Ito K, Saijo M, Takada A
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Journal Title
Clinical and Vaccine Immunology 17(11)
Pages: 1723-1728
Peer Reviewed
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[Journal Article] J.Virol.2010
Author(s)
Matsuno K, Kishida N, Usami K, Igarashi M, Yoshida R, Nakayama E, Shimojima M, Feldmann H, Irimura T, Kawaoka Y, Takada A
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Journal Title
Different potential of C-type lectin-mediated entry between Marburg virus strains. 84(10)
Pages: 5140-5147
Peer Reviewed
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[Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein.2010
Author(s)
Watanabe Y, Hiraoka W, Igarashi M, Ito K, Shimoyama Y, Horiutchi M, Yamamori T, Yasui H, Kuwabara M, Inagaki F, Inanam O
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Journal Title
Biochem Biophys Res Commun 394(3)
Pages: 522-528
Peer Reviewed
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