2010 Fiscal Year Final Research Report
The study of molecular polymorphisms of glycophorin A oligomer in bovine red blood cells associated with the bovine piroplasmosis resistibility
| Project/Area Number |
21780282
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OTSUKA Yayoi Hokkaido University, 大学院・獣医学研究科, 博士研究員 (30396303)
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| Co-Investigator(Renkei-kenkyūsha) |
INABA Mutsumi 北海道大学, 大学院・獣医学研究科, 教授 (00183179)
SATO Kota 北海道大学, 大学院・獣医学研究科, 准教授 (50283974)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 牛ピロプラズマ病 / グライコフォリンA / 受容体 / シアル酸 / シアロ糖蛋白質 |
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| Research Abstract |
The present study demonstrated that a high-molecular weight sialoglycoprotein with apparent molecular masses >500 kDa (GPA oligomer) in bovine erythrocyte membranes consists of glycophorin A, glycophorin B, and CD58. GPA oligomers showed variety among individuals in their protein compositions, contents and sizes. Moreover, there were served different glycophorin B variants and this variation in glycophorin B species appeared to represent the blood group system F. Moreover, diversity of GPA oligomer might be involved in protozoan infectivity into bovine red cells.
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