2012 Fiscal Year Final Research Report
Effect of oral tributyrin in intestinal injury
| Project/Area Number |
21780291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Kagawa Prefectural College of Health Sciences |
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Principal Investigator |
MIYOSHI Makoto 香川県立保健医療大学, 保健医療学部, 助教 (50433389)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 酪酸 / トリブチリン / 腸管 integrity |
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| Research Abstract |
Oral tributyrin, prodrug of butyrate, increased plasma butyrate level in inferior vena cava and expression of PPARγ and apoptosis in small and large intestine. And tributyrin attenuated intestinal injury associated with lipopolysaccharide injection. The increase in pro-inflammatory cytokine TNF-α/IL-1β mRNA level, pathological changes including hemorrhage, and high mortality were improved by tributyrin. Oral tributyrin increased plasma butyrate level and attenuated intestinal injury in endotoxemic rats.
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