2010 Fiscal Year Final Research Report
Development of Synthetic Methodology for Multi-substituted Heterocycles via Benzyne Intermediate and Its Application for Natural Product Synthesis
| Project/Area Number |
21790006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
OKANO Kentaro Tohoku University, 大学院・薬学研究科, 助教 (30451529)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 有機化学 / 有機合成化学 / 天然物合成化学 |
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| Research Abstract |
Synthetic methodology for multi-substituted heterocycles was developed utilizing the high reactivity of benzyne intermediate. Magnesium bisamide was proved to be the best base for the benzyne generation and nucleophilic addition to construct heterocyclic skeletons. The resulting anion species reacted with a variety of electrophiles to give functionalized heteroaromatic compounds. The tricyclic skeleton of isobatzelline and discorhabdins was constructed using the reaction conditions.
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Research Products
(21 results)
