2010 Fiscal Year Final Research Report
Developments and applications of multifunctional catalytic molecules based on the creation of novel asymmetric reaction space
| Project/Area Number |
21790007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
NEMOTO Tetsuhiro Chiba University, 大学院・薬学研究院, 講師 (80361450)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ジアミノホスフィンオキシド / 触媒的不斉合成 / 有機触媒 / スピロ化合物 / タングトリン / パラジウム / アリル位置換反応 |
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| Research Abstract |
The present researches can be summarized as follow. (1) We developed a Pd-catalyzed intramolecular ipso-Friedel-Crafts allylic alkylation of phenols, which provided a new access to spirocyclohexadienones. (2) Novel bidentate-type diaminophosphine oxide preligands were developed and applied to catalytic organic synthesis. In addition, catalytic asymmetric total synthesis of tangutorine was achieved. (3) Novel bifunctional hydrogen bond-donor catalysts based on a 4,5-diaminoxanthene skeleton were developed. These catalysts were applicable to enantioselective conjugate addition of prochiral nucleophiles to nitrostyrenes for constructing an all carbon quaternary stereocenter.
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[Presentation] Catalytic Asymmetric Total Synthesis of Tangutorine2010
Author(s)
Tetsuhiro Nemoto, Eri Yamamoto, Robert Franzen, Takashi Fukuyama, Riliga Wu, Toshihiko Fuakamachi, Hiroshi Kobayashi, Yasumasa Hamada
Organizer
The 21^<st> French-Japanese Synposium on Medicinal and Fine Chemistry
Place of Presentation
Kyoto, Japan
Year and Date
2010-05-10
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