2010 Fiscal Year Final Research Report
Synthetic Study of Antitumor Alkaloids Haouamines Using a Cascade Cyclization
| Project/Area Number |
21790011
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
TANIGUCHI Tsuyoshi Kanazawa University, 薬学系, 助教 (60444204)
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| Project Period (FY) |
2009 – 2010
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| Keywords | カスケード反応 / 溝呂木-ヘック反応 / プメラー型反応 / 全合成 / ハオウアミン / ラジカル反応 / 鉄触媒 |
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| Research Abstract |
Formal synthesis of haouamine A has been achieved using cascade Mizoroki-Heck cyclization to give an indenotetrahydropyridine core. On the other hand, synthesis of a core of haouamine B using Pummerer-type cyclizations was difficult. However, this synthetic study gave us an opportunity to develop a new methodology such as iron-catalyzed radical reactions using hydrazine compounds and nitration reactions of alkenes.
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