2010 Fiscal Year Final Research Report
Synthesis of multi-substituted aromatic compounds based on controlling regioselectivities of benzyne reactions
| Project/Area Number |
21790020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IKAWA Takashi University of Shizuoka, 薬学部, 助教 (20453061)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ベンザイン / ボロン酸誘導体 / ケイ素化合物 / 置換芳香族化合物 / 位置選択性 / Diels-Alder反応 / 求核付加反応 |
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| Research Abstract |
The regioselective nucleophilic addition reaction of amines to 3-silylbenzynes and Diels-Alder reaction of 3-borylbenzynes, both of which are generated under mild conditions, have been developed. These new reactions can be regarded as the synthetic methods of broad multi-substituted aromatic compounds because silicon and boron substituents on aromatic ring can be converted to various functional groups.
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