2011 Fiscal Year Final Research Report
Synthetic study of GKK1032s, directed toward the development of new anticancer drugs
| Project/Area Number |
21790022
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science (2010-2011)
Tohoku Pharmaceutical University (2009) |
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Principal Investigator |
ABE Hideki 東京薬科大学, 生命科学部, 准教授 (00328551)
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| Project Period (FY) |
2009 – 2011
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| Keywords | GKK1032類 / 不斉合成 / 分子内Diels-Alder反応 / 合成化学 / 多環性アルカロイド / 抗腫瘍性 / 有機化学 / 薬学 |
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| Research Abstract |
Stereoselective synthesis of the tricyclic decahydrofluorene core(ABC-ring system) of GKK1032s has been accomplished. All attempt for the construction of 13-membered ring of the target compounds(intramolecular Mitsunobu reaction, intramolecular Reformatsky reaction, intramolecular Still coupling reaction, ring closing metathesis, and intramolecular Friedel. Crafts reaction) was failed.
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