2010 Fiscal Year Final Research Report
Control of axial chirality and development of novel bioactive compounds with asymmetric axes.
| Project/Area Number |
21790025
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
TABATA Hidetsugu Teikyo University, 薬学部, 助手 (80445634)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 動的キラリティー / 軸不斉 / ビアリール骨格 / アトロプ異性体 / カップリング反応 |
|---|
| Research Abstract |
The dibenzo[b,d]azepin-6-one nucleus, which constitutes the scaffold of the γ-secretase inhibitors LY-411575 and its analogs, has two sp^2-sp^2 asymmetric axes. We are interested in stereochemistry of the two asymmetric axes, and have reported the atropisomeric properties of dibenzo[b,d]azepin-6-one derivatives. Herein, we present a study on the stereochemistry of the eight-membered analog, dibenzo[b,d]azocin-6-one derivatives.
|
