2010 Fiscal Year Final Research Report
Development of artificial pancreas based on an LBL microcapsule
| Project/Area Number |
21790031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Katsuhiko 東北大学, 大学院・薬学研究科, 助教 (80400266)
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| Project Period (FY) |
2009 – 2010
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| Keywords | クロカプセル / インスリンDD / 機能性薄膜 / 交互累積膜 / フェニルボロン酸 |
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| Research Abstract |
Sugar-sensitive microcapsules containing insulin (artificial pancreas) were prepared by a layer-by-layer (LBL) deposition of alginic acid and phenylboronic acid-modified poly(allylamine) on the surface of a calcium carbonate (CaCO_3) microparticle in which insulin had been embedded, followed by dissolution of the CaCO_3 core. The sugar-triggered release of insulin was explained on the basis of decomposition of the microcapsules, which in turn was caused by competitive binding of added sugar to the phenylboronic acid moieties in the LbL film.
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Research Products
(5 results)
