2011 Fiscal Year Final Research Report
Evaluation of crystal and molecular state of pharmaceutical salt by MQ-MAS NMR method
| Project/Area Number |
21790032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | MQ-MAS NMR / 固体NMR / 低含量製剤 / 水和物 |
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| Research Abstract |
Multi Quantum Magic Angle Spinning (MQ-MAS) NMR spectroscopy characterized the pseudopolymorphs of sodium naproxen and cromolyn sodium. The detailed structure and molecular state of the pseudopolymorphs were clarified. The discrimination of the pseudopolymorphs in low dose formulation was achieved. This study revealed that MQ-MAS method could be a powerful technique to evaluate pharmaceutical formulations.
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