2010 Fiscal Year Final Research Report
Development of nanoparticles using intelligent polymers as a treatment for inflammatory disease
| Project/Area Number |
21790041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
AYANO Eri Keio University, 薬学部, 研究員 (10424102)
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| Project Period (FY) |
2009 – 2010
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| Keywords | インテリジェントポリマー / DDS / ナノ粒子 / PNIPAAm / 相転移温度 / PLA |
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| Research Abstract |
We designed the temperature-responsive and biodegradable block copolymer, poly (N-isopropylacrylamide-co-DL-lactide) (PNIPAAm-co-PLA) was synthesized by ring-opening polymerization of DL-lactide and used as a carrier for an ideal drug delivery system. PNIPAAm exhibits a thermally reversible phase transition in aqueous solution at 32 oC. This transition temperature is called the lower critical solution temperature (LCST). When the temperature is below the LCST of the thermo-responsive block, nanoparticles are formed with the hydrated outer shell and the hydrophobic inner core. When the temperature exceeds the LCST, the outer shell shrinks and becomes hydrophobic. Our temperature-responsive nanoparticles successfully exhibited thermo-responsive drug release and cellular uptake while possessing biodegradable character.
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