2010 Fiscal Year Final Research Report
Investigation of change of serum glycoproteins with aging and its application to aging marker
| Project/Area Number |
21790050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分析化学 |
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| Research Abstract |
Since structural alterations of glycans are known to be associated with changes of physiological environments, glycans have been received attention as target molecules for clinical biomarkers. In this study, we analyzed N- and O-glycans of glycoproteins from rat serum samples using capillary electrophoresis, and found that N-glycans showed disitinctive changes with age or high-fat diet. The present results indicate that glycans will be one of the useful biomarkers for aging.
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[Journal Article] Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line high-performance liquid chromatography-matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and sequential exoglycosidase digestion.2009
Author(s)
Kinoshita M, Ohta H, Higaki K, Kojima Y, Urashima T, Nakajima K, Suzuki M, Kovacs KM, Lydersen C, Hayakawa T, Kakehi K.
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Journal Title
Anal Biochem. 388(2)
Pages: 242-253
Peer Reviewed
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[Remarks] ホームページ等
