2010 Fiscal Year Final Research Report
Mechanistic Study on the Pro-oxidant Effects by Antioxidants
| Project/Area Number |
21790053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
NAKANISHI Ikuo National Institute of Radiological Sciences, 重粒子医科学センター, 主任研究員 (70356137)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 活性酸素種 / 抗酸化物質 / 薬学 / 有機化学 / 反応機構 / ラジカル / プロオキシダント / 金属イオン |
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| Research Abstract |
The mechanism of generation of reactive oxygen species (ROS) by antioxidants as pro-oxidants was investigated in the presence of a metal ion or under basic conditions. Quercetin, one of polyphenolic antioxidants, was suggested to show the pro-oxidant activity via a complex formation between its carbonyl oxygen and a metal ion. The phenolate anion derived from a vitamin E model in the presence of a strong base showed a strong electron-donating ability to reduce molecular oxygen to produce ROS.
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