• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

A study to elucidate how AdRP-associated mutations in splicing factors affect the spliceosome formation pathway

Research Project

  • PDF
Project/Area Number 21790056
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

MAITA Hiroshi  Hokkaido University, 大学院・薬学研究院, 講師 (60431318)

Project Period (FY) 2009 – 2010
Keywords分子生物学 / pre-mRNAスプライシング
Research Abstract

Although autosomal dominant retinitis pigmentosa (AdRP) is a tissue specific disease, disease associated mutations were found in several constitutive splicing factors consisting the spliceosome as well as genes in photo signal transduction pathway. To elucidate the mechanism how abnormality of general splicing factors triggers AdRP, we tried to detect the effect of the mutations on the cellular splicoeosme levels using a newly developed reporter. The reporter experiment suggested that the cell may regulate the spliceosome level to adjust the surrounding environment.

  • Research Products

    (3 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Spliceosome discards intermediates via the DEAH box ATPase Prp43p.2010

    • Author(s)
      Mayas R.M., Maita H., Semlow D.R., Staley J.P.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 107

      Pages: 10020-10025

    • Peer Reviewed
  • [Presentation] Detection of free U5 snRNP levels in living cells2010

    • Author(s)
      Maita, H., Ariga, H.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2010-12-10
  • [Presentation] Split Luciferaseを応用した新規U5 snRNP検出法の確立2009

    • Author(s)
      Maita, H., Ariga, H.
    • Organizer
      第11回日本RNA学会年会
    • Place of Presentation
      新潟県
    • Year and Date
      2009-07-28

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi