2010 Fiscal Year Final Research Report
Role of mitochondria in neural circuit formation
| Project/Area Number |
21790059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOYAMA Ryuta The University of Tokyo, 大学院・薬学系研究科, 助教 (90431890)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経生物学 |
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| Research Abstract |
In this study, we used in vivo and in vitro models (Muramatsu, Koyama and others., Brain 133:60-75, 2010) of neonatal seizures to test the hypothesis that abnormally increased mitochondrial numbers produce surplus ATP and induce axonal branches under hyperexcitable conditions. We have revealed that axonal mitochondria rewire neural circuits in the epileptic brain via the mechanisms highlighted below.
〓Mitochondria accumulate in axons after seizures.
〓The accumulation of axonal mitochondria is neuronal activity-dependent.
〓Axons release neurotrophin to attract mitochondria in adjacent axonal shafts.
〓Localized mitochondria induce and maintain axonal branches via ATP production.
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[Remarks] ホームページ等
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[Remarks] 学会発表1は、ハイライトシンポジウムに採択された。
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[Remarks] 学会発表10は、優秀発表賞に選ばれた。
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[Remarks] 学会発表12は、優秀発表賞に選ばれた。
